Toxicity to theophylline
WebTheophylline toxicity continues to be a commonly encountered clinical problem. Patients may present with a vast array of toxic manifestations, including life-threatening cardiovascular and neurologic toxicity. WebAug 31, 2024 · High-risk cases include the following: Acute overdose with theophylline levels higher than 80 mcg/mL. Chronic toxicity with levels higher than 40 mcg/mL. Patients …
Toxicity to theophylline
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WebJun 27, 2024 · The excess circulating catecholamines cause serious clinical effects that are associated with theophylline toxicity. Depending on the dose and route of administration, … WebIn contrast, when signs or symptoms of theophylline toxicity are present, a serum sample should be obtained as soon as possible, analyzed immediately, and the result reported to …
WebTheophylline causes sympathetic stimulation (mediated by beta-adrenergic receptors) Common features of toxicity include . Hypokalemia . Reported in 25%-50% of patients … WebSep 6, 2024 · Theophylline, a relatively weak bronchodilator, is less effective than inhaled beta-2 agonists, and does not add benefits in acute bronchospasm. If beta agonists are not available, an oral theophylline loading dose can be used as a temporary measure.
WebAug 31, 2024 · Common side effects of theophylline may include: nausea, vomiting, diarrhea; headache; sleep problems ( insomnia ); tremors; sweating; or. feeling restless … WebPotentially toxic: peak: >30.0 mcg/mL, trough: >8.0 mcg/mL. Toxic concentration: Peak: >40 mcg/mL; Trough: >10 mcg/mL Half-life: Children: 1.6 to 2.5 hours Adults with normal renal function: ~2-3 hours ESRD: 17 to …
WebThe therapeutic range of serum theophylline concentration is 10 to 20 μg/ml. Virtually all patients with serum levels greater than 30 μg/ml have some manifestations of theophylline toxicity,, most commonly tachycardia, nausea, and anxiety. Severe theophylline intoxication may be complicated by tachyarrhythmias, seizures, shock, and death. , ,
WebPinard E, Riche D, Puiroud S, Seylaz J. Theophylline reduces cerebral hyperaemia and enhances brain damage induced by seizures. Brain Res 1990; 511:303. Minton NA, Henry JA. Acute and chronic human toxicity of theophylline. Hum Exp Toxicol 1996; 15:471. Kearney TE, Manoguerra AS, Curtis GP, Ziegler MG. ldi wom chileWebApr 5, 2024 · Theophylline typically needs to be taken in relatively high doses for maximum respiratory benefits. Because of the potential risk of toxicity and side effects, methylxanthines are not usually recommended as first-line agents for lung conditions. ldj chemicalsWebFeb 16, 2024 · Manifestations of theophylline toxicity. * Drug Interactions DRUG INTERACTIONS Theophylline interacts with a wide variety of drugs. The interaction may be pharmacodynamic, i.e., alterations in the therapeutic response to theophylline or another drug or occurrence of adverse effects without a change in serum theophylline … ldi whiskeyWebJun 27, 2024 · The excess circulating catecholamines cause serious clinical effects that are associated with theophylline toxicity. Depending on the dose and route of … ldj a-maize-ing heat biomass furnaceWebWe treated 14 patients who had an initial serum theophylline concentration greater than 30 μg/ml (48. 3 ± 19. 4 μg/ml) and symptoms of theophylline toxicity with oral activated … ldiy ighting for wall shelvesWebA 60 kg adult ingests, as one dose, five tablets of theophylline each containing 250 mg. Determine whether or not clinical signs of theophylline toxicity are likely to be observed and calculate the time at which the peak drug concentration is reached. Show clearly all steps in your calculations. ldiy little boys bean bag chairWebMar 5, 2016 · Many of the typical symptoms of theophylline toxicity are non-specific, which further perpetuates the challenges of recognition in a long-term user. These include nausea, vomiting, fatigue, tachycardia and central nervous system (CNS) effects such as dizziness and seizures [ 3 ]. ldje cleaning services