Sphingofungin
WebNatural sphingosine analogues containing a β, β′-dihydroxy α-amino acid framework demonstrate potent antifungal or immunosuppressive activity and are potential candidates for the development of chemical tools or pharmaceuticals. This Highlight Review presents the total syntheses of sphingosine analogues, myriocin, mycestericins and sphingofungin … WebAn efficient and convenient stereoselective synthesis of sphingofungin F from L-(+)-tartaric acid, which utilizes Sharpless asymmetric epoxidation of allylic alcohol and Lewis acid-catalyzed intramolecular epoxide-opening reaction with an N-nucleophile, to introduce the other two desired stereogenic centers. As a new member of the sphingofungin family, …
Sphingofungin
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Web19. sep 2013 · The asymmetric total synthesis of sphingofungin E, which has potent immunosuppressive activity, is described. Key steps include asymmetric … Web19. sep 2013 · We describe herein the asymmetric total synthesis of sphingofungin E, which has potent immunosuppressive activity. Key steps include asymmetric desymmetrization by bromolactonization, stereocontrolled construction of four contiguous stereogenic centers through allylic C–H oxidation and epoxide ring opening, regioselective elongation of a …
Web1. sep 1999 · A Modular Approach to the Antifungal Sphingofungin Family: Concise Total Synthesis of Sphingofungin A and C. Raguž L, Peng CC, Kaiser M, Görls H, Beemelmanns C. Angew Chem Int Ed Engl, 61(5):e202412616, 07 Dec 2024 Cited by: 1 article PMID: 34677894 PMCID: PMC9300042. Free to read & use Web代查代借服务. 国际科技引文服务. 重点领域信息门户
Web12. okt 2011 · Abstract. Transition metal-catalyzed decarboxylative cross-coupling reactions have recently emerged as a new and important category of organic transformations that find versatile applications in the construction of carbon-carbon and carbon-heteroatom bonds. The use of relatively cheap and stable carboxylic acids to … Web19. sep 2013 · We describe herein the asymmetric total synthesis of sphingofungin E, which has potent immunosuppressive activity. Key steps include asymmetric desymmetrization …
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WebLoop is the open research network that increases the discoverability and impact of researchers and their work. Loop enables you to stay up-to-date with the latest discoveries and news, connect with researchers and form new collaborations. outstanding filipino photographersoutstanding filipino animatorsWeb6. apr 2024 · Stereocontrolled Total Synthesis of Sphingofungin E; Synthesis of Optically Active Heterocyclic Compounds by Preparation of 1,3-Dinitro Derivatives and E... Highly Enantioselective Desymmetrization of Meso Anhydrides by a Bifunctional Thiourea-Based Organoc... ChemInform Abstract: Desymmetrization of meso-Anhydrides Utilizing (S) … outstanding finance checkerWeb11. jún 2024 · In particular, sphingofungin E ( 1 ) and F ( 2 ) contain a quaternary center at the C-2 position. Their structures, especially the structure of sphingofungin E, are strikingly similar to myriocin ( 3 ), which has been reported as a potent immunosuppressive agent. 2 In consequence of many organic chemists having been interested in the structure ... raised urate in pregnancyWeb19. sep 2013 · The asymmetric total synthesis of sphingofungin E, which has potent immunosuppressive activity, is described. Key steps include asymmetric desymmetrization by bromolactonization, stereocontrolled construction of four contiguous stereogenic centers through allylic C–H oxidation and epoxide ring opening, regioselective elongation of a … outstanding filipino youthWebSphingofungin H C22H39NO6 413.277739 LMSP01080084 Sphingofungin G C22H37NO6 411.262089 « Previous Next » Showing 101 to 109 of 109 results 1 2 ... outstanding filipino researchersWebGaich2Group!Seminar! Sebas8an!Krüger! NNH NH N O O HO H HH Br agelasta’nA!! key!step: PdAAA!! Asymmetric!allylic!alkylaon !reviews: B.!M.!Trost,!JOC, 2004, 69 ... raised urates in pregnancy