Web12 apr. 2024 · Venglustat alters sphingolipid levels and reduces α-synuclein (aSyn) in brain of Thy1-aSyn transgenic mice. (A, B) Sphingolipids in plasma (HexCer represents almost exclusively glucosylceramide [GlcCer], n = 17 wild-type [wt] control, n = 17 transgenic [tg] control, n = 14 tg on venglustat); (C–F) sphingolipids in cerebral cortex (GlcCer, … Web11 okt. 2024 · It has been reported that EMT plays a detrimental role in the developmental processes of fibrosis caused by ocular cGVHD and that TL can restrain TNF-α- and TGF-β-induced EMT.[11, 20] As evidenced by our investigation, when allo-BMT recipients mice were medicated with TL, the increase of TNF-αin sera was suppressed and the mRNA …
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