Hepatocyte identity
Web15 feb. 2015 · The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) regulates various cellular activities, including redox balance, detoxification, metabolism, autophagy, proliferation, and apoptosis. Several studies have demonstrated that Nrf2 regulates hepatocyte proliferation during liver regeneration. The aim of this study was to …
Hepatocyte identity
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WebMaterials and Methods: Human umbilical vein mesenchymal stem cells (UVMSCs) were incubated for 2 weeks in the medium containing hepatocyte growth factor; they were also treated with the medium containing oncostatin M for another 2 weeks. The Web12 jul. 2024 · The hepatocyte reprogramming was under tight cooperative control of a net-work of NASH-activated transcription factors (TFs), as exemplified by Elf3 and Glis2. Indeed, Elf3 and Glis2 controlled hepatocyte identity and fibrosis-dependent hepatokine genes targeting disease-associated hepatic stellate cell (HSC) gene programs.
Webhepatocyte‐specific rubicon ko ameliorates liver steatosis in mice on an hfd Although KO mice showed a modest, but significant, reduction in body weight after 4 months on an HFD (Fig. 6 D and Supporting Fig. S6A ), the most striking difference was the reduction in liver volume to approximately normal levels, which was accompanied by significantly … Web1 mei 2016 · The hepatocyte mediates many liver functions by carrying out a multitude of activities at the cellular level. Despite the regenerative capacity of the liver in vivo, primary human hepatocytes (PHHs) are not viable in vitro, and they are in limited supply.Although micropatterned co-culture can extend the viability of PHHs ex vivo (Khetani and Bhatia, …
WebHepatic identity is typified by the expression of a unique complement of genes. Hepatocellular identity is developmentally established and post-natally preserved by a … WebObjective:To study whether human RPE cells in vitro would express hepatocyte growth factor(HGF) and its receptor c-Met in protein and gene levels.Methods:Human RPE cells were cultured in vitro.HGFR/c-Met expressions of RPE cells were detected by immunohistochemistry (IH) and reverse transcriptase polymerase chain reaction(RT …
Web8 mrt. 2024 · Consistent with the paradigm that mIDH enforces a differentiation block in cancer cells and, correspondingly, that mIDH inhibition acts as a differentiation therapy, we observed increased expression of hepatocyte marker genes, including targets of the master transcriptional regulator of hepatocyte identity HNF4α [liver-specific genes: normalized …
Web10 apr. 2024 · In the future, Sosa-Pineda said she wants to drill deeper and examine the impact of Wnt signaling on transcriptional regulation of hepatocytes, more precisely identifying how Wnt signaling contributes to proper hepatocyte identity. Ruihua Ma, PhD, a former postdoctoral fellow in the Sosa-Pineda laboratory, was the first author of the study. hawker 4000 specsWeb9 mrt. 2024 · j The hepatic identities of EPS-Heps, F-PHHs, EPS cells, reprogrammed hepatocytes (hiHeps) 12 and cells from other studies (GSE103078 and GSE98710) were … hawker 4000 specificationsWeb1 jun. 2011 · The pivotal role of HNF4α in the induction and maintenance of hepatocyte differentiation should also be ascribed to its capacity to continuously repress the mesenchymal program; thus, both H NF4α activator and repressor functions are necessary for the identity of hepatocytes. The concept that cellular terminal differentiation is stably … bossybutclassyWeb17 aug. 2024 · Our findings show that direct chemical reprogramming can generate hepatocyte-like cells with high-quality physiological properties, providing a paradigm for establishing hepatocyte identity in fibroblasts and demonstrating the potential for chemical reprogramming in organ/tissue repair and regeneration therapies. bossy bullys ltdWeb13 apr. 2024 · Probing healthy and pre-malignant liver disease by single-nucleus RNA sequencing, Carlessi et al. identify a disease-associated hepatocyte (daHep) state. daHeps are prevalent in liver disease and display a high mutational burden, suggesting they constitute a pre-malignant compartment. Higher frequencies of daHeps predicted an … bossybrow discount codeWebimpairment in hepatocyte identity caused by Nrf2 deficiency during liver regeneration. This event is characterized by the reduction in hepatocyte size, the activation of hepatic progenitor markers, the loss of HNF4a protein, and the downregulation of a subset of genes associated with important hepatocyte functions. hawker 400xpr tcdsWeb23 mrt. 2024 · We showed that forced re-expression of hepatocyte nuclear factor 4 alpha (HNF4α) can reprogram dysfunctional hepatocytes from terminally cirrhotic livers to function again, both in culture and in vivo, through expansion of new hepatocytes or stem cells and without the need for regeneration. 16 bossy brothers: luke read online