WebClinVar archives and aggregates information about relationships among variation and human health. WebDDB1 and CUL4 associated factor 17. Normal Function. The DCAF17 gene provides instructions for making a protein whose function is unknown. The gene is active (expressed) in several organs and tissues in the body, including the brain, skin, and liver. Within cells, the protein produced from this gene is found in the nucleolus, which is a small ...
DCAF13 is essential for the pathogenesis of preeclampsia through …
WebOct 1, 2024 · Male infertility is a common condition affecting at least 7% of men worldwide and is often genetic in origin. Using whole exome sequencing, we recently discovered … WebDDB1 is also a component of an ubiquitin-E3 ligase complex and functions as substrate or adapter protein between Cullin 4A (Cul4A) and CUL4-associated factors (DCAFs) to target substrates for ubiquitination. CUL4-DDB1 E3-ligase complex regulates the selective proteolysis of key proteins in DNA repair, replication and transcription. hopital saint palais numero
Expression profiling of WD40 family genes including DDB1- and …
WebMar 29, 2024 · HIV-1 Vpr co-localizes with the Cul4A ubiquitin ligase complex (Cul4A, DCAF1, and DDB1) in the cellular chromatin compartment. PubMed. vpr. HIV-1 Vpr induces the degradation of APOBEC3G through VprBP binding and participation of the proteasome, leading to a reduction in APOBEC3G encapsidation into virions. PubMed. WebDCAF13P3 (DDB1 And CUL4 Associated Factor 13 Pseudogene 3) is a Pseudogene. Additional gene information for DCAF13P3 Gene HGNC (43868) NCBI Entrez Gene … WebUsing whole exome sequencing, we recently discovered three hemizygous, likely damaging variants in DDB1- and CUL4-associated factor 12-like protein 1 (DCAF12L1) in men with azoospermia. DCAF12L1 is located on the X-chromosome and as identified by single cell sequencing studies, its expression is enriched in human testes and specifically in ... hopital saint paul hanoi