2024 Cytoplasmic sox10

Cytoplasmic sox10

Author: nnha

August undefined, 2024

WebIn accord with its function as transcription factor, Sox10 contains two nuclear localization signals and is most frequently detected in the nucleus. In this study, we report that … WebAug 11, 2015 · SOX10 was negative in 10 cases of ITACs and 2 cases of non-ITACs, and positive in all other adenocarcinomas. The sensitivity of CK7-, CK20+, SOX10- and CDX2+ in primary ITACs of the sinonasal tract were 70.0%, 90.0%, 100%, 100%, respectively, and the specificity were 100%, 96.8%, 93.5%, 100%, respectively. Conclusions:

Characterization of GFP-Sox10. (A and B) Subcellular lo

WebJan 4, 2024 · Confocal microscopy (Fig. 4e, f) demonstrated predominantly cytoplasmic localization in most of the SOX2x3Mut-transduced NSC, whether they had initiated differentiation (white arrowheads) or not... WebMar 15, 2024 · SOX10 shows an increased specificity for soft tissue tumors of neural crest origin compared with S100 ( Appl Immunohistochem Mol Morphol 2012;20:445 ) MITF1 and SOX10 can be used to differentiate melanoma in situ from actinic keratosis with … university of washington fosters

[CK7, CK20, SOX10 and CDX2: expressions and diagnostic values …

WebMay 5, 2009 · Others have shown that Sox10 is a nucleocytoplasmic shuttling protein. We extend this observation and demonstrate that, in the cytoplasm, Sox10 is peripherally associated with the mitochondrial outer membrane. Both Sox10 and ARMCX3 are expressed in mouse brain and spinal cord as well as several cell lines. Overexpression … WebIn addition, a fourth pattern with cytoplasmic AE1/AE3 and nuclear SOX10 was observed in a subset of carcinomas, most notably triple-negative breast cancers. Conclusions: … WebSox10 shuttles between the nucleus and the cytoplasm. Since Sox10 can be found in the nucleus as well as in the cytoplasm, we addressed the question whether Sox10 has nucleocytoplasmic shuttling activity. An interspecies heterokaryon analysis was performed as originally described by Pinol-Roma and Dreyfuss . university of washington gene editing

Sox10 is an active nucleocytoplasmic shuttle protein, and ... - PubMed

SOX10/keratin dual-color immunohistochemistry: An effective

WebSOX10/keratin dual-color immunohistochemistry: An effective first-line test for the workup of epithelioid malignant neoplasms in FNA and small biopsy specimens SOX10/keratin dual-color immunohistochemistry: An effective first-line test for the workup of epithelioid malignant neoplasms in FNA and small biopsy specimens WebFeb 6, 2024 · We found that Sox10 induced the expression of Fbxo9, which is both required and sufficient for regulating Neurog2 protein stability via ubiquitination that was … university of washington gender ratioWebJun 20, 2014 · Cytoplasmic staining for the pan-melanoma cocktail and nuclear staining for SOX10 and MITF were scored by 2 pathologists (J.C. and Y.G.). Positive staining in >1% … university of washington gap year

"WebMar 21, 2024 · SOX10 (SRY-Box Transcription Factor 10) is a Protein Coding gene. Diseases associated with SOX10 include Peripheral Demyelinating Neuropathy, Central … " - Cytoplasmic sox10

Cytoplasmic sox10

SOX10 ablation severely impairs the generation of postmigratory neura…

WebNov 29, 2024 · SOX10 immunoexpression is increasingly recognized in salivary gland tumors, including but not limited to those with myoepithelial, serous acinar, and inter … WebSOX10 and/or S100 protein immunopositivity in conjunction with rearrangement of the PLAG1 gene assisted in reclassification of a subset of oncocytomas as oncocytic variants of PA and ME. Therefore, we recommend to include S100 protein and SOX10 IHC when diagnosing tumors with predominantly oncocytoma-like differentiation.

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WebSOX10 and S100 both stained 100% of DM and SCM, whereas Pan Melanoma stained 50% (Figure 3, Table 1). Normal lymph node was negative for SOX10 and Pan Melanoma but was strongly positive for S100 (Figure 4). The melanoma triple cocktail (Fast Red only) and the sequential double stain of SOX10 (DAB) and Pan Melanoma WebJan 31, 2024 · The majority of tumors demonstrated 1 of 3 distinct patterns: 1) malignant melanomas with nuclear SOX10 (sensitivity of 94% and specificity of 95%); 2) epithelioid/pleomorphic sarcomas negative for …

WebApr 5, 2013 · Appropriate positive and negative controls were used for each antibody. Nuclear staining of >10% tumor cells was considered positive for SOX10 and p63; cytoplasmic staining for Smooth muscle actin... WebAug 27, 2024 · Animal studies have indicated that SOX10 is one of the key transcription factors regulating the proliferation, migration and differentiation of multipotent neural …

WebApr 4, 2024 · Orthologous to human SOX10 (SRY-box transcription factor 10). [provided by Alliance of Genome Resources, Apr 2024] Sox10 SRY (sex determining region Y)-box 10 [ (house mouse)] Gene ID: 20665, updated on 4-Apr-2024. Summary. ... and nervous system development. Located in cytoplasm and nucleus. Is extrinsic component of … WebNov 4, 2024 · SOX10 positivity is also commonly expressed in both mixed tumors and myoepitheliomas (~80%), but is only present in a minor percentage of myoepithelial carcinomas (Fig. 3f) . Other markers of ...

WebA weak cytoplasmic staining reaction in cells with a strong nuclear staining reaction was accepted. Participation Number of laboratories registered for SOX10, run 55 211 Number of laboratories returning slides 204 (97%) Results 204 laboratories participated in this assessment. 181 (89%) achieved a sufficient mark (optimal or good).

WebAug 20, 2015 · Results: SOX-10 showed exclusive nuclear positivity in 100% of the uveal melanoma cases (38/38). HMB-45 showed cytoplasmic positivity in 97.3 (37/38). … recap weatherizationWebApr 1, 2024 · We have previously shown that SOX10 is expressed in one hundred percent of primary human melanoma samples and that its expression is crucial for melanoma initiation, but also maintenance of... recap walking deadWebSox10 shuttles between the nucleus and the cytoplasm. Since Sox10 can be found in the nucleus as well as in the cytoplasm, we addressed the question whether Sox10 has nu- cleocytoplasmic shuttling ... recap walkerWebNordic Immunohistochemical Quality Control, SOX10 run 60 2024 Page 1 of 9 Assessment Run 60 2024 Transcription factor SOX-10 (SOX10) Purpose Evaluation of the technical performance, level of analytical sensitivity and specificity of IHC tests among ... a weak cytoplasmic staining reaction of ganglion/neuronic cells in the appendix was accepted ... recap wasteSOX10 is used as an immunohistochemistry marker, being positive in: • Neuroectodermal neoplasms of neural crest origin, especially: Melanoma, although desmoplastic melanomas may be only focally positive. Nevus • SOX10 immunohistochemistry in a dermal nevus, showing positively stainin… university of washington germanWebSOX10 and S100 both stained 100% of DM and SCM, whereas Pan Melanoma stained 50% (Figure 3, Table 1). Normal lymph node was negative for SOX10 and Pan Melanoma but … recap weldfit recap weatherization program