Cyclophosphamide elimination half-life
WebThe elimination half-life of cyclophosphamide is 5 to 9 hours, and alkylating activity is undetectable in the plasma of most patients 24 hours after a dose of 12 mg/kg. 1 Plasma concentrations of cyclophosphamide are not clinically useful predictors of … WebJul 31, 2024 · These metabolites interfere with the growth of susceptible rapidly proliferating malignant cells. Pharmacokinetics Following IV administration, elimination half-life (t ½) ranges from 3 to 12 hours with total body clearance (CL) values of 4 to 5.6 L/h. Pharmacokinetics are linear over the dose range used clinically. When
Cyclophosphamide elimination half-life
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WebThe elimination half-life (t ½) of intravenously administered cyclophosphamide ranges from 3 to 12 hours; the total body clearance is 4 to 5.6 L/h. The pharmacokinetic dose range used is clinically linear. It is administered at 4.0 g/m 2 over a 90-minute infusion period. The kinetics of the drug are described by first-order renal elimination. WebRoute of elimination. Cyclophosphamide is eliminated primarily in the form of metabolites. 10-20% is excreted unchanged in the urine and 4% is excreted in the bile following IV …
WebRepeated administration of cyclophosphamide at approximately 30-60 day intervals did not appear to alter its plasma half-life but did appear to increase its urinary excretion. Daily … WebJul 27, 2024 · Usual dosage when used as a single agent is 60–75 mg/m 2, given as a single dose at 21-day intervals; consider the lower dose for patients with poor performance status, inadequate bone marrow reserves secondary to old age, prior therapy, or marrow infiltration with malignant cells.
WebSep 30, 2012 · The elimination half-life of cyclophosphamide ranges between 5–9 hours over a large concentration range. The plasma half-life appears to be shorter for children … Tablets: • 1. 25 mg of Cyclophosphamide, USP. Tablets are white with blue flecks and imprinted with 25 on one side and BXT on the other. • … See more Cyclophosphamide Tablets are contraindicated in patients with: • 1. A history of severe hypersensitivity reactions to Cyclophosphamide, any of its metabolites, or to … See more
WebCovariate relationships that trended toward significance for cyclophosphamide included decreased serum albumin and increased elimination rate constant (-0.427, P = 0.061, 95% CI 0.738, 0.034), increased urinary protein excretion and increased AUC (0,∞) (-0.392, P = 0.064, 95% CI -0.699 to 0.037), decreased C (max) (0.367, P = 0.085, 95% CI … matt vesty earthmovingWebCyclophosphamide (CP) was nearly, if not completely, cleared from plasma by 24 h after its administration. The plasma half-life of CP ranged from 2.15 to 8.15 h; it decreased following higher doses and was shorter than that previously reported for adult patients. heritage family pharmacy burlington iowaWebUse in Cancer. Cyclophosphamide is approved to be used alone or with other drugs to treat: Acute lymphoblastic leukemia (ALL) in children. Acute monocytic leukemia. Acute … matt vespa earthjusticeWebDownload scientific diagram Comparison of half-life (A) and elimination constant (B) of cyclophosphamide by CYP3A5 and POR genotype. from publication: Population … matt vena height and weightWebDec 11, 2024 · Cyclophosphamide-induced sterility may be irreversible in some patients. Advise patients on the potential risks for infertility [see … matt vespa townhall mediaWebCyclophosphamide (CP) is a distinguished anticancer and immune subduing medicament. Conversely, regardless of its pervasive proven use, it retains limitations of neurotoxicity. … heritage family specialty foodsWebApr 23, 2024 · PDF Cyclophosphamide (CPA) containing chemotherapy regimen is the standard of care for breast cancer treatment in sub-Saharan Africa. ... Comparison of half-life (A) and elimination constant (B ... heritage family services edmonton