2024 Cisplatin nephropathy

Cisplatin nephropathy

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August undefined, 2024

WebCisplatin-nephropathy model mice exhibited elevated levels of serum IS accompanied by elevated levels of blood urea nitrogen and serum creatinine. Furthermore, intraperitoneal administration of IS in mice promoted tumor growth and metastasis. Finally, we found that the MasR agonist Ang-(1-7) suppressed the IS-mediated effects on cell ... WebJul 7, 2007 · Despite the clinical effectiveness of cisplatin as an anti-tumour drug, its nephrotoxic side effect has significantly restricted its use. In spite of prophylactic …

Kidney disease - Wikipedia

WebDec 21, 2024 · Previous publications have revealed that NOX4 overexpression exacerbated tubular damages in diabetic nephropathy , ischemia/reperfusion- or cisplatin-induced AKI [37,39], obstructive nephropathy , and hypertensive nephropathy . Thus, NOX4 can be up-regulated in various scenarios, which might be dependent upon its transcriptional or post ... WebIn order to confirm the additional adverse effects of KU55933 on cisplatin-induced DNA damage and to elucidate the For all groups, data are means ± SEM, *p < 0.05 vs control, # p < 0.05 vs ... honesty in the police

Molecular mechanisms of cisplatin-induced …

WebKidney disease, or renal disease, technically referred to as nephropathy, is damage to or disease of a kidney. Nephritis is an inflammatory kidney disease and has several types according to the location of the inflammation. Inflammation can be diagnosed by blood tests. Nephrosis is non-inflammatory kidney disease. WebAug 14, 2024 · Nephrotoxicity associated with cisplatin administration is common and unwanted adverse effect which has significantly restricted its clinical use [ 1 ]. Both acute and chronic nephrotoxicities associated with cisplatin tend to occur more frequently at higher doses or especially after repeated administration [ 2 ]. WebCisplatin ATN AKI, hypomagnesemia, renal sodium Chronic interstitial ﬁbrosis and cyst formation wasting, CKD Ifosfamide ATN Fanconi syndrome (partial or complete) AKI ESRD Methotrexate Crystal nephropathy Nonoliguric AKI Pemetrexed ATN AKI AIN CKD Tubular atrophy and interstitial ﬁbrosis Nephrogenic diabetes insipidus Ipilimumab AIN AKI honesty is the best policy in filipino

Cisplatin Nephrotoxicity: A Review - Neil Kurtzman

Cisplatin-induced renal salt wasting syndrome - PubMed

WebOct 1, 2024 · We identified Compound-6c(Cpd-6c) as having the best activity and examined its protective effect against cisplatin nephropathy both in vivo and in vitro in cisplatin-stimulated tubular epithelial cells (TECs). Our results showed that Cpd-6c restored renal function more effectively than Ru, as evidenced by reduced blood urea nitrogen and … WebSep 15, 2008 · In thrombotic microangiopathy, organ damage is caused by platelet thrombi in the microcirculation, as in thrombotic thrombocytopenic purpura. 30 Mechanisms of renal injury secondary to drug-induced... honesty is the best policy in spanishWebApr 12, 2024 · In recent years, the onco-nephrology field has acquired a relevant role in internal medicine due to the growing number of cases of renal dysfunction that have been observed in cancer patients. This clinical complication can be induced by the tumor itself (for example, due to obstructive phenomena affecting the excretory tract or by neoplastic … honesty is the best policy tarp

"WebCisplatin was the first platinum compound to be introduced as a chemotherapeutic agent with antineoplastic activity against a wide variety of solid tumors. Renal impairment with … " - Cisplatin nephropathy

Cisplatin nephropathy

Sirtuin 7 Deficiency Ameliorates Cisplatin-induced Acute Kidney …

WebSide effect and toxicity management Prophylaxis and treatment Prevention and management of cisplatin nephrotoxicity ID: 184 v.3 Endorsed This document is an … WebJan 1, 1996 · CsA nephropathy was introduced as a PRD in the ERA-EDTA Registry in 1985 and, despite its rarity, is of particular interest as a new iatrogenic entity resulting from CsA administration, mainly in solid organ transplantation. In 1985, two new patients commenced RRT in Europe, and the number increased to 59 in 1991–93.

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Webcisplatin-induced nephrotoxicity has not been well studied. Intracellular Events that Damage Renal Cells The in vivo mechanisms of cisplatin nephrotoxic-ity are … WebCisplatin is an important chemotherapeutic drug for the treatment of solid tumors but often causes nephropathy as part of the off-target toxicity. Iron accumulation and related damage were implicated in cisplatin-induced kidney injury.

WebDec 13, 2024 · Cisplatin and carboplatin are platinum-based antineoplastic agents. Approximately 30% of patients receiving cisplatin have acute kidney injury (AKI), and it is not unusual for subsequent treatment to be limited [].On the other hand, carboplatin, which was developed as a derivative of cisplatin in the same platinum formulation, is … WebNephropathy can be associated with some therapies used to treat cancer. The most common form of kidney disease in cancer patients is Acute Kidney Injury (AKI) which can …

WebMyeloma cast nephropathy is an obstructing disorder of renal tubules, caused by precipitation of Bence Jones proteins. Myeloma-like cast nephropathy (MLCN) has … WebOct 22, 2024 · Cisplatin is a commonly used anticancer drug, but nephrotoxicity is a dose-limiting adverse effect. Recent experimental and clinical observations have demonstrated that multiple injections of...

WebJul 22, 2024 · Cisplatin nephropathy is a representative chemotherapeutic agent-related AKI. The molecular mechanisms underlying cisplatin-induced AKI have long been the subjects of research, and a number of studies have demonstrated the involvement of mitochondrial dysfunction, oxidative stress, inflammation, and apoptosis in renal tubular …

WebOct 13, 2024 · Cisplatin is nephrotoxin that can cause both acute kidney injury and chronic kidney disease. Accumulation of cisplatin in renal tubular cells induces various intracellular stresses, including... honesty lesson ks2WebNov 11, 2024 · Cisplatin (CDDP), a platinum drug, has been universally utilized to treat bladder cancer, ovarian cancer and other solid tumors ( Dasari and Tchounwou, 2014 ). However, the dominant factor restricting the clinical use of cisplatin is its nephrotoxicity ( Zhu et al., 2015 ). honesty is your best defense and offenseWebwww.karger.com honesty is the best policy signageWebApr 12, 2024 · Cisplatin is a highly effective anti-cancer agent used in the treatment of solid organ tumors, such as head and neck, lung, breast, testis, and ovarian cancers 1, 2. Although cisplatin has... honesty is the first chapter of wisdom quoteWebFeb 2, 2024 · 5.1 Cisplatin-Induced Nephrotoxicity. Cisplatin, ... Let us pay attention to whether, the body affected by nephropathy also causes further nephrotoxicity by breaking the balanced relationship between the two pathways, in addition to nephrotoxicity caused by the crosstalk of Nrf2 and NF-κB. When exploring whether diabetes aggravates I/R … honesty long definitionWebDiabetic nephropathy is characterized by inflammation, fibrosis, and oxidant stress, pathologic features that are shared by many other … honesty is the best policy quotesWebProphylaxis and treatment Prevention and management of cisplatin nephrotoxicity ID: 184 v.3 Endorsed This document is an evidence based summary to complement treatment protocols and includes background and rationale for specific point of care actions. It is not intended to be a comprehensive literature review of all available evidence. On this page honesty libramont